Important finding for the Phd candidate Amanda Rundblad at the Phd programmmes in health sciences and her coworkers that the intake of oxidised Fish oil (FO) and high-quality FO differently affect lipid composition in lipoprotein subclasses, with a more favourable effect mediated by high-quality FO. Their study presented in the publication “High-quality fish oil has a more favourable effect than oxidised fish oil on intermediate-density lipoprotein and LDL subclasses: a randomized controlled trial” is the first randomised controlled trial investigating the effects of supplementation with FO of different quality in healthy, normolipidaemic subjects on distribution and composition of lipoprotein subclasses measured with NMR spectroscopy.
The authors stated that FO supplementation reduces the risk of Cardiovascular disease (CVD.) However, it is not known if FO of different qualities have different effects on lipoprotein subclasses in humans. The aim of their project was to investigate the effects of oxidised FO and high-quality FO supplementation on lipoprotein subclasses and their lipid concentrations in healthy humans. Fifty-four subjects completed a double-blind randomised controlled intervention study. High-quality FO reduced the concentration of intermediate-density lipoprotein (IDL) particles and large, medium and small LDL particles, as well as the concentrations of total lipids, phospholipids, total cholesterol, cholesteryl esters and free cholesterol in IDL and LDL subclasses compared with oxidised FO and HOSO. Hence, high-quality FO and oxidised FO differently affect lipid composition in lipoprotein subclasses, with a more favourable effect mediated by high-quality FO. In future trials, reporting the oxidation levels of FO would be useful. The results from this study may indicate that FO with different qualities elicit different effects on blood lipids). The authors stated that a 10% reduction in LDL-cholesterol in 40-year-old men has been associated with a 54% reduced risk of ischaemic heart disease). Thus, their results on LDL-cholesterol might have a clinical relevance